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Literature summary for 2.4.1.90 extracted from
- Serum galactosyltransferase isoform changes in rheumatoid arthritis (2004), J. Rheumatol., 31, 1513-1520.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| extracellular | several isoforms in serum from patients with rheumatoid arthritis and from healthy individuals | Homo sapiens | - |
- |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mn2+ | - |
Homo sapiens |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | the enzyme utilizes different glycoproteins and glycolipids as substrates, patients with rheumatoid arthritis have a higher content of an acidic isoform compared to healthy individuals, the isoform is not associated with inflammation per se but specifically with rheumatoid arthritis | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
several isoforms | - |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| glycoprotein | the enzyme is 75% more active in its desialylated form than in the sialylated form | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| serum | several isoforms in serum from patients with rheumatoid arthritis and from healthy individuals | Homo sapiens | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
activity of sialylated and desialylated enzyme, overview | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | the enzyme utilizes different glycoproteins and glycolipids as substrates, patients with rheumatoid arthritis have a higher content of an acidic isoform compared to healthy individuals, the isoform is not associated with inflammation per se but specifically with rheumatoid arthritis | Homo sapiens | ? | - |
? | |
| UDP-galactose + ovalbumin | - |
Homo sapiens | UDP + ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| beta1,4-galactosyltransferase | - |
Homo sapiens |
| GTase | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6.8 | - |
assay at | Homo sapiens |
pI Value
| Organism | Comment | pI Value Maximum | pI Value |
|---|---|---|---|
| Homo sapiens | amount of the diverse isoforms is different in serum from patients with rheumatoid arthritis and in serum from healthy individuals, overview | - |
additional information |
| Homo sapiens | diverse isoforms from patients with rheumatoid arthritis and from healthy individuals separated by isoelectric focusing, profiling, overview | 5.95 | 4.05 |
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Release 2023.1 (January 2023)
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